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KMID : 0380620160480060560
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Korean Journal of Food Science and Technology
2016 Volume.48 No. 6 p.560 ~ p.564
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Antimicrobial activities of actinonin against Bacillus cereus
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Jung Dong-Yun
Yum Su-Jin
Yu Yeon-Cheol
Kim Jong-Heon
Lee Byung-Hwi
Jang Hoon-Nyung
Jeong Hee-Gon
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Abstract
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The objective of this study was to investigate the anti-Bacillus cereus activity of actinonin. Actinonin inhibited the growth of B. cereus in a dose dependent manner. The growth-inhibitory activity of actinonin was evaluated using a broth micro-dilution method, and minimum inhibitory concentration (MIC) and agar disk diffusion tests. B. cereus showed high susceptibility to actinonin in a concentration-dependent manner and MIC was determined to be 0.192 μg/mL. Additionally, 1 and 2 mM actinonin induced formation of B. cereus inhibition zones. In addition, as compared to B. cereus alone, B. cereus added with 10 μM actinonin showed a lower level of cytotoxicity in HeLa cells in vitro. Thus, this study revealed that actinonin could be a potential source of a natural antimicrobial agent or a pharmaceutical component against B. cereus.
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KEYWORD
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Actinonin, Bacillus cereus, antimicrobial agent
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